Copyright HEMO SAPIENS INC.

Monitoring page of all HOTMAN^® Systems is an informational tool designed to inform the clinician about:

• Patient's personal information - name, gender, height, weight, age and identification number (yellow bar at the top of the page)
• Digital values of all processed parameters and their physical dimension (yellow windows at the right side of the screen)
• For parameters that exhibit normal range (all blood flow-related parameters), analog presentation in form of a yellow diamond on a background of blue horizontal bars, showing how the parameter's value compares to its normal range. Normal ranges are gender, age and clinical state dependent. Normal minima are the white numbers in the left column within blue bars, maxima are in the right column.
  Vertical stratification reflects the clinical importance (Oxygen transport dynamics at the top, followed by perfusion blood flow below, then hemodynamic state, hemodynamic modulators....).
• The processed four analog signals are displayed in the windows on the left:
  ECG,
  dZ/dt (an image of aortic blood flow),
  Z (an image of aortic compliance)
  Rate of respiration (deflection upward represents the rate of inspiration, deflection downward the rate of expiration).
• Information about Therapeutic goal selected (NORMAL or POSTOPERATIVE) at the bottom of the page
• Footnote (if used) within the yellow horizontal bar at the bottom of the page.

At the beginning of the measurement, the HOTMAN^® System can be set into one of two different modes of keyboard data entry, resulting in several different data display formats of Monitoring Screen. The mode setting depends on availability of values of hemodynamic/oxygen transport parameters.
There are two mode settings available:

• ALL NONINVASIVE MEASUREMENTS, where the operator can enter/update via the keyboard the digital values of:
  Arterial blood pressure - (S/D) [torr = mmHg]
  Hemoglobin - (Hgb) [g/dl]
  Saturation of O in arterial blood (measured by Pulse Oximetry) - (SpO) [%]
  Temperature - (Temp) [Celsius or Fahrenheit]
  Weight - (W) [kg or lbs] in case of a longitudinal measurements over a long period of time
  .
• INVASIVE DATA AVAILABLE, where the operator can enter/update via the keyboard the digital values of:
  Pulmonary Artery Occluded Pressure - (PAOP) [torr = mmHg]
  Central Venous Pressure - (CVP) [torr = mmHg]
  Saturation of O in mixed venous blood - (SvO) [%]
  Arterial blood pressure - (S/D) [torr = mmHg]
  Hemoglobin - (Hgb) [g/dl]
  Saturation of O in arterial blood (measured by Pulse Oximetry) - (SpO) [%]
  Temperature - (Temp) [Celsius or Fahrenheit]
  Weight - (W) [kg or lbs] in case of longitudinal measurements over a long period of time

Depending on measurement mode set and absence/presence of values of entered parameters, the Monitoring Screen of HOTMAN^® BAS System can attain several formats:

• ALL NONINVASIVE MEASUREMENTS set (System uses normal mean values of CVP = 4 and PAOP = 9 in calculations of LSWI and SSVRI).
  In this example, the SpO/SpO measurement was not performed (or the Hgb value was not entered); the HOTMAN^® BAS System cannot process the Oxygen Transport Dynamics data and just processes and displays a patient's hemodynamics. In place of the Oxygen Transport Dynamics Parameters is just a sign HEMODYNAMICS ONLY (please note Normal Therapeutic Goal selected):

• ALL NONINVASIVE MEASUREMENTS set (System uses normal mean values of CVP = 4 and PAOP = 9 in calculations of LSWI and SSVRI):
  SpO and Hgb values were measured and entered and the HOTMAN^® BAS System thus processes the Oxygen Delivery Dynamics (Normal Therapeutic Goal selected):

• INVASIVE DATA AVAILABLE set (System allows entry of CVP, PAOP, SpO, Hgb and SvO):
  In this example all invasively-obtained parameters were measured and their values were entered via the keyboard and the System then processed complete Oxygen Transport Dynamics data (including the Oxygen Consumption Index, VOI). Please note the NORMAL THERAPEUTIC GOAL selected:

• INVASIVE DATA AVAILABLE set (System allows entry of CVP, PAOP, SpO, Hgb and SvO):
  In this example the Hgb value was not entered, so the System could not process any Oxygen transport dynamics data, however, actual measured values of CVP and PAOP were known, were entered and are displayed. Please note the POSTOPERATIVE THERAPEUTIC GOAL was selected.